PopPK Auto-Diagnose

Upload PK data. The engine runs adaptive structure selection across 1- and 2-compartment models — escalating only when the simpler structure is unreliable — plus a fractional-order screen, and returns a verdict with statistical guardrails. Designed for DMPK leads who need a 2-minute diagnostic before opening a full population analysis.

Early access. PopPK (the nlmixr2 population engine) is open now — confirm your email for one free analysis, same as NCA, Tumor and Drug Release. It runs a heavier fit (minutes, not seconds), so expect a longer queue. Questions? Contact us →

🔒 TLS 1.2+ in transit 🛡 AES-256 at rest ⏱ Auto-deleted within 1 hour 🇪🇺 EU-only (Frankfurt) Privacy policy →

1 · Upload dataset

📂

Click or drag a CSV file

NONMEM-format expected (ID · TIME · DV · AMT · EVID)

⬇ No data handy? Download an example CSV to try it

▶ Accepted CSV format · click to expand

Required columns (case-insensitive, NONMEM aliases accepted):

TIME — time since dose. Aliases: time, t, tad, time_h, time_hr, tiempo, temps, zeit
DV — observed concentration. Aliases: dv, conc, concentration, y, obs, value, concentracion, konzentration, valeur

Optional columns: ID, AMT (dose), EVID (event ID), MDV (missing DV flag), RATE, DVID, CMT.

Header flexibility — punctuation, case, and parenthesised units are tolerated. Time (h), TIME_H, time-h and timeh all map to TIME. ES/FR/DE headers (tiempo, temps, zeit, etc.) are also accepted.

Minimum size: 4 distinct time points.

Example:

ID,TIME,DV,AMT,EVID
1,0,0,320,1
1,0.5,4.2,0,0
1,1,6.0,0,0
1,2,5.5,0,0
1,4,3.8,0,0
1,8,2.0,0,0
1,12,1.1,0,0
1,24,0.4,0,0

Do NOT submit datasets with direct identifiers (names, dates of birth, contact details). Use pseudonymised IDs.

Dose (mg)

Route

Email — your report will be sent here We only use your email to send your report. No spam. Privacy.

Report language / Idioma del informe

Question of interest — optional (ICH M15 §2.1.1) What decision is this analysis meant to inform?

Context of use — optional (ICH M15 §2.1.2) The role and scope of the model, and what other evidence you have.

Consequence of a wrong decision — optional (ICH M15 §2.1.4) Model risk is derived from this and the model influence; without both, the report states that it is not derivable.

Starting…

You can close this tab — we'll email the report when it's ready.

This report contains computational results. Pharmacological interpretation and clinical decisions are the responsibility of the client's expert team. FractaLPK does not provide medical, pharmacological, or regulatory advice.